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He spoke of his dreams of finding a girlfriend and starting a family after coming out of surgery.
He also revealed he hoped to set up an organisation to help other overweight people around the world get back into shape.
Cristiano Ronaldo sent him a signed Real Madrid shirt at the start of last month to inspire him to continue losing weight and become healthier.
Moreno, who lived in Ciudad Obregon in the north-western state of Sonora, said he felt as if he had received a Christmas gift before Christmas.
News of his death was revealed by relatives on his Facebookpage.
Publicist Carmen Palacios confirmed later: “Andres died at 8.30am on Christmas Day in an ambulance from a heart attack as he was taken from his house to San Jose Hospital.”
He is due to be buried later today.
Moreno walked for the first time in three years on December 2 after his op and subsequent surgery on an unrelated stomach hernia.
Speaking after his feat, he said: “My legs were trembling like anew-born foal’s but thankfully I can stand up by myself and walk by myself.”
Moreno, a former police officer, admitted to being dumped by his wife as his weight ballooned after he turned 20.
He said: “I realised I was putting on more and more weight and getting bigger but it was like a snowball I couldn’t stop.
“I lost my wife, who I lived with for three years and left me because I was fat.
“Friends and family would visit me and when they went I was left alone crying and sad because of my situation and begging God to put me back on the right path.
“I hit rock-bottom when I couldn’t get out of bed and go to the toilet or wash myself.”
Specialist Jose Antonio Castaneda said ahead of the op he performed on Moreno on October 28, that he wouldn’t have lasted another five years without it and described the death as “unexpected.”
The previous record for the world’s fattest man was also held by a Mexican, Manuel Uribe, from Monterrey, who weighed 88 stone.
He died last year aged 48.
Britain’s fattest man, 65-stone Carl Thompson, died in June just a month after pleading for help to try and change the 10,000 calories-a-day diet he was warned would kill him
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